Selective activation of Fas/Fas ligand-mediated cytotoxicity by a self peptide.

Selective activation of Fas/Fas ligand-mediated cytotoxicity by a self peptide

To study how MHC-associated self antigens may regulate the function of T cells in the periphery, we generated CD8+ T cell lines specific for a single residue variant of a self peptide. The self peptide (GAYEFTTL) was isolated from H-2-Kb class I MHC molecules immunopurified from tumor cells. CD8+ CTL lines from H-2b mice were generated against a variant peptide, pE4R, (arginine for glutamic aci...

Selective Speciation of Ferric Iron by a New Heterocyclic Ligand

The synthesis and analytical applications of the new heterocyclic ligand are described. The complexation reaction of the ligand with some cations was studied in aqueous methanol at room temperature using the spectrophotometric method. Results revealed that only the absorption spectra of the Fe (III)–ligand complex show a high redshift of the absorption maximum in the aqueous methanol soluti...

Antitumor Cytotoxicity Mediated by Ligand-activated Human Va24 NKT Cells

Human Va24 NKT cells bearing an invariant Va24JaQ antigen receptor, the counterpart of the murine Va14 NKT cells, are activated by the specific ligand, a-galactosylceramide (a-GalCer) in a CD1d-dependent manner. Here, we demonstrate that the a-GalCer-activated Va24 NKT cells exert a potent perforin-dependent cytotoxic activity against a wide variety of human tumor cell lines. In addition, we de...

Altered Peptide Ligand-Mediated TCR

بررسی جامعه شناسی منطق بر اساس کتاب "weaving self-evidence a sociology of logic" by "claude rosental"

این رساله از چهار فصل تشکیل شده است.نویسنده کتاب در فصل اول در تلاش است تا به جهان دور از دسترس منطق دانان دسترسی پیدا کند در این راستا در ابتدا به سابقه و پیشینه جامعه شناسی ریاضیات و منطق می پردازد. او رویکرد های جامعه شناختی و تجربی به منطق را مورد مداقه قرار می دهد و از این میان شیوه روش قوم شناختی رابر می گزیند. رزنتال اعتقاد دارد نگاه صلب و تغییر ناپذیر به منطق ناصواب است. منطق همانند هر ...